A desk top computer can more easily be damaged during transportation than a laptop. According to two well known computer specialists, the best way to travel with your desk top computer in a vehicle or motorhome is to place it on its side with the USB ports down. Also lay it on something soft that forms a supportive cushion. The laptop computer can safely be placed in its proper carrying case, strap it down and zip the case shut; the carrying case is usually padded.
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